Pathology MCQs

Pathology MCQs

5/13/2025, 12:32:00 PM

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Pathology MCQs

5/13/2025, 12:31:36 PM

Correct answer is 3rd trimester: ➡️1st trimester villi – loose, open stroma; thick cytotrophoblast + syncytiotrophoblast; few central capillaries with nucleated fetal RBCs ➡️2nd trimester villi – denser stroma; syncytiotrophoblast + thinning/patchy cytotrophoblast; more peripheral capillary loops with mostly anucleate RBCs ➡️3rd trimester villi – dense, fibrous stroma; syncytiotrophoblast only (very thin); abundant capillary loops immediately beneath syncytium; prominent syncytial knots; fibrin deposition on villous surface; well-developed vasculo-syncytial membranes.

Pathology MCQs

2/16/2025, 2:18:31 PM

📢 Pathology Challenge: Can You Diagnose This? 🔬🧐 🚨 Case: GI biopsy from a 58-year-old immunocompromised male presenting with persistent diarrhea. 🩺 Histology shows small, basophilic, round structures attached to the brush border of enterocytes (🔬 see arrows). ❓ What’s your diagnosis? Answer the Poll question ! 👇👇 💡 Hint: Think opportunistic infections in immunosuppressed patients!

Pathology MCQs

2/16/2025, 2:19:28 PM

Options

Pathology MCQs

2/12/2025, 10:22:24 AM

Correct answer is : Hereditary hemochromatosis (HH). It is an autosomal recessive disorder characterized by increased iron absorption and deposition, primarily affecting the liver, pancreas, and skin, leading to cirrhosis, diabetes, and bronze pigmentation (“bronze diabetes”). ✅The most common mutation associated with HH is *C282Y in the HFE gene*, responsible for 85-90% of hereditary hemochromatosis cases in Northern European populations. ✅The H63D mutation is less common and is associated with a milder form of iron overload, often asymptomatic unless found in compound heterozygous form (C282Y/H63D). ✅Mutations in the HJV gene lead to an altered hemojuvelin protein that cannot function properly. Without adequate hemojuvelin, hepcidin levels are reduced and iron homeostasis is disturbed- resulting in hereditary hemochromatosis type 2. ✅The ATP7B mutation is associated with Wilson’s disease, a disorder of copper metabolism. Histopathology of Hereditary Hemochromatosis (H&E Findings in Liver Biopsy): ➡️Iron deposition: Brownish granular hemosiderin pigment within hepatocytes (Perl’s Prussian blue stain confirms iron). ➡️Zone 1 hepatocyte involvement: Iron accumulates first in periportal hepatocytes, progressing to the rest of the liver. ➡️Fibrosis and cirrhosis: Advanced cases show bridging fibrosis leading to cirrhosis. ➡️Absence of inflammation: Unlike other liver diseases, HH does not have significant inflammatory infiltration. Reference: MacSween’s Pathology of the Liver, 8th Edition

Pathology MCQs

2/9/2025, 6:49:09 AM

Options

Pathology MCQs

2/9/2025, 6:46:10 AM

Liver biopsy of a 48 year old man who presented with deranged LFT and brownish discoloration of the skin. What is your diagnosis?

Pathology MCQs

2/1/2025, 10:29:21 AM

Correct answer is B: Sézary syndrome is a leukemic form of cutaneous T-cell lymphoma (CTCL) characterized by circulating malignant CD4+ T-cells. The key flow cytometry findings are: *CD4/CD8 ratio >10:1 due to a monoclonal expansion of abnormal CD4+ T-cells* Loss of CD7 and CD26, markers usually expressed on normal T-cells *Monoclonal T-cell receptor (TCR) gene rearrangement confirming malignancy* Why Other Options Are Incorrect? ❌ A. CD4/CD8 ratio <1 with loss of CD3 → More suggestive of cytotoxic T-cell disorders, not Sézary syndrome. ❌ C. Predominantly CD 14 and CD 16 positive cells → Suggests Monocytic lineage. ❌ D. CD5 and CD23 co-expression → Suggests chronic lymphocytic leukemia (CLL), not Sézary syndrome. Complete explanation: https://youtu.be/o1fMu2gbu_g?si=QbQQQDaEKx66LTz6