Inflammation_Mediators* 􏰀 1st line in Tissue -- Macrophages 􏰀 1st line in Blood -- Neutrophils 􏰀 1st line on Surface --Skin 􏰀 Major scavengers --Macrophages 􏰀 Phagocytosis done by --Neutrophils and macrophages 􏰀 Opsonization -- C3b and Fc fragment of igG 􏰀 Most potent Chemo tactic Factor--LTB4 > C5a 􏰀 Pain--Bradykinin > Prostaglandins E2 􏰀 IL-1 and TNF – Fever mediator 􏰀 Prostaglandins F2, E2 and D2 – Vasodilation 􏰀 Late mediator of Inflammation – PG & Leukotriens 􏰀 Initial mediator of inflammation – Histamine 􏰀 Anaphylotoxin -C3a -C5a 􏰀 Membrane attack complex -C5-9 􏰀 Fibrinopeptide increase vascular permeability 􏰀 Neuropeptide cause neurogenic inflammation