Immune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy that presents with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. Worldwide annual incidence of iTTP is 2 cases per million to 6 cases per million. Common presenting features of iTTP include neurologic symptoms, abdominal pain or nausea, and fever. ➡️ Learn more about the pathophysiology, epidemiology, diagnosis, and treatment of iTTP in this JAMA review: https://ja.ma/4kpRneB