*_Call for Applications: Grand Challenges RCT on STIs and Reproductive Tract Infections in Non-Pregnant Women_* . The Bill & Melinda Gates Foundation through Grand Challenges invites letters of intent for a Randomized Controlled Trial (RCT) to evaluate STI screening and reproductive health outcomes in sub-Saharan Africa Purpose To generate causal evidence on pelvic inflammatory disease (PID) and related health outcomes following gonorrhea, chlamydia, and trichomoniasis To compare etiologic STI screening with syndromic management and assess effectiveness, cost, and long-term impact Funding Between USD 8 million and USD 10 million per project, Project duration up to 48 months Eligibility Academic institutions, nonprofits, for-profits, international organizations, and government agencies Projects must be based in sub-Saharan Africa Preference for African-led, women-led, early-career, and LMIC-based research teams Key Dates Applications open: 2 June 2025 Letter of Intent (LOI) deadline: 7 July 2025 at 11:30 AM Pacific Time Informational webinar: 17 June 2025 at 7:00–8:00 AM PT Full proposals by invitation in August 2025 Awards announced by late 2025 or early 2026 Required Study Design Primary outcome must be PID, Secondary outcomes may include chronic pelvic pain, infertility, ectopic pregnancy Studies must include gender-informed approaches and community engagement Data collection on symptoms, STI incidence, treatment, cost, and behavioral indicators How to Apply Submit your LOI via the Grand Challenges portal, Prepare your project summary, budget, and other required forms Attend the webinar for guidance before submission Join the channel below for similar updates https://whatsapp.com/channel/0029VaFJJsYKbYMNE9HYHM27 Apply Now https://gcgh.grandchallenges.org/challenge/randomized-controlled-trial-sexually-transmitted-infections-stis-and-reproductive-tract #stiresearch #grandchallenges #rct #womenhealth #gatesfoundation #subsaharanafrica #pid #reproductivehealth #globalhealth _Our GGA policy States:Don't make any payments at any stage._