New research shows that overactive brain cells called AgRP neurons in the hypothalamus play a crucial role in type 2 diabetes, separate from obesity or food intake. In diabetic mice, scientists silenced these neurons and saw blood sugar levels return to normal for months, even though the mice didn’t lose weight or eat less. This discovery challenges the long-held belief that diabetes is mainly caused by obesity and insulin resistance. Instead, it suggests that the brain itself has a powerful influence on blood sugar control. Researchers used a genetic method to block communication of these neurons, which led to the surprising diabetes remission. Interestingly, these neurons seem to impact blood sugar but not obesity, meaning treatments targeting them might fix diabetes without affecting body weight. The findings also connect to previous studies where a brain-injected peptide, FGF1, caused similar remission by suppressing these neurons. Some current diabetes drugs like Ozempic may work partly by calming AgRP neurons, though this needs more [email protected] https://www.facebook.com/share/p/1YFUEr14Ph/