Lipid modification drug treatment Unless contraindicated, treatment with a high-intensity statin (such as atorvastatin 20–80 mg daily) will be offered at diagnosis of stroke or TIA by secondary care. The aim of statin therapy is to reduce non-HDL cholesterol by more than 40%. If this reduction is not achieved within 3 months, consider adherence, diet, lifestyle, and increasing dose (if appropriate) — discuss with a stroke specialist if unsure.