LINK https://www.odontologiavirtual.com/2025/06/anaphylactic-shock-in-dental-anesthesia.html Anaphylactic shock is a rare but potentially life-threatening systemic hypersensitivity reaction that can occur during or after dental anesthesia. Triggered by rapid IgE-mediated responses or direct mast cell activation, this reaction leads to widespread mediator release—including histamine—causing profound vasodilation, bronchoconstriction, and often, cardiovascular collapse.