⛑️Modêrn Hêalth-updatês💊🇨🇦🇺🇲 e-Pharmacy
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💡💊Photosensitivity can occur in patients taking tetracycline antibacterial drugs. ☀️However, this reaction is more common with: • doxycycline • demeclocycline
💡💊Pleuromutilins are a newer class of antibacterial drugs that act as protein synthesis inhibitors, targeting the 50S subunit. Examples: ☀️lefamulin - used for community-acquired pneumonia ☀️retapamulin - used topically to treat impetigo
💡💊 *Haloperidol and Weight Gain* Haloperidol, a first-generation (typical) antipsychotic, is generally associated with less weight gain compared to many second-generation (atypical) antipsychotics like olanzapine or clozapine. However, weight gain can still occur in some individuals, particularly with long-term use. ☀️A systematic review of antipsychotics showed that weight gain with haloperidol is relatively modest compared to atypical antipsychotics. ☀️Studies report an average weight gain of 1-3 kg (2.2–6.6 lbs) over the first year of treatment.
💡💊Co-administration of fusidic acid with statins significantly increases the risk of rhabdomyolysis.
💡💊 *Doxylamine* is an antihistamine prescribed in combination with pyridoxine (vitamin B6) to prevent morning sickness in pregnant women (hyperemesis gravidarum).
💡💊⚠️ Antibiotics that are generally considered safe for use in people with renal failure (without requiring dose adjustment) include: 🔸Clindamycin 🔸Doxycycline 🔸Moxifloxacin 🔸Azithromycin 🔸Linezolid
💡💊𝗗𝗼𝘅𝘆𝗰𝘆𝗰𝗹𝗶𝗻𝗲 is the drug of choice for 𝗥𝗶𝗰𝗸𝗲𝘁𝘁𝘀𝗶𝗮 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻𝘀, including 𝗥𝗼𝗰𝗸𝘆 𝗠𝗼𝘂𝗻𝘁𝗮𝗶𝗻 𝘀𝗽𝗼𝘁𝘁𝗲𝗱 𝗳𝗲𝘃𝗲𝗿, due to its superior pharmacokinetics and efficacy. ☀️ 𝗗𝗼𝘅𝘆𝗰𝘆𝗰𝗹𝗶𝗻𝗲 is widely used for acne treatment due to its 𝗮𝗻𝘁𝗶-𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗼𝗿𝘆 properties and effectiveness against 𝗣𝗿𝗼𝗽𝗶𝗼𝗻𝗶𝗯𝗮𝗰𝘁𝗲𝗿𝗶𝘂𝗺 𝗮𝗰𝗻𝗲𝘀.
💡💊Paroxetine can be used to treat premature ejaculation. One 20mg tablet is taken 3-4 hours before sex. ☀️Priligy is an oral tablet containing dapoxetine used to help with premature ejaculation.
💡💊𝗗𝗼𝗺𝗽𝗲𝗿𝗶𝗱𝗼𝗻𝗲 ☀️works by 𝗯𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗱𝗼𝗽𝗮𝗺𝗶𝗻𝗲 (𝗗𝟮) 𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿𝘀 in the chemoreceptor trigger zone (CTZ) and gastrointestinal tract. ☀️unlike metoclopramide, domperidone 𝗱𝗼𝗲𝘀 𝗻𝗼𝘁 𝘀𝗶𝗴𝗻𝗶𝗳𝗶𝗰𝗮𝗻𝘁𝗹𝘆 𝗰𝗿𝗼𝘀𝘀 𝘁𝗵𝗲 𝗕𝗕𝗕, reducing the risk of extrapyramidal symptoms (EPS) such as dystonia and tardive dyskinesia. ☀️𝗿𝗲𝗰𝗼𝗺𝗺𝗲𝗻𝗱𝗲𝗱 𝗮𝗱𝘂𝗹𝘁 𝗱𝗼𝘀𝗲 is 10 mg up to three times daily (maximum 30-40 mg per day), with treatment duration limited to the shortest possible time due to cardiac risks. ☀️𝗰𝗼𝗺𝗺𝗼𝗻𝗹𝘆 𝘂𝘀𝗲𝗱 𝘁𝗼 relieve nausea and vomiting caused by delayed gastric emptying, chemotherapy, or Parkinson’s disease treatments. ☀️𝗰𝗮𝗻 𝗽𝗿𝗼𝗹𝗼𝗻𝗴 𝘁𝗵𝗲 𝗤𝗧 𝗶𝗻𝘁𝗲𝗿𝘃𝗮𝗹, increasing the risk of torsades de pointes and sudden cardiac death, particularly at high doses or in patients with predisposing factors. ☀️blocks dopamine (D2) receptors in the pituitary gland, leading to an 𝗶𝗻𝗰𝗿𝗲𝗮𝘀𝗲 𝗶𝗻 𝗽𝗿𝗼𝗹𝗮𝗰𝘁𝗶𝗻 𝘀𝗲𝗰𝗿𝗲𝘁𝗶𝗼𝗻, which enhances breast milk production. ☀️𝗻𝗼𝘁 𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗳𝗼𝗿 𝗺𝗼𝘁𝗶𝗼𝗻 𝘀𝗶𝗰𝗸𝗻𝗲𝘀𝘀, as it does not act on histamine (H1) or muscarinic receptors, which are involved in vestibular balance.
💡💊Acyclovir is a prodrug that is phosphorylated by viral thymidine kinase into its active form, acyclovir triphosphate. This active form inhibits viral DNA polymerase, preventing viral replication. ☀️Nephrotoxicity (Crystalline nephropathy—hydrate well!). ☀️Probenecid & Cimetidine → Increase acyclovir levels. ☀️Dose adjustment required in renal impairment. ☀️Early initiation (within 72 hours) improves outcomes in VZV infections. ☀️IV formulation preferred for severe cases like encephalitis.