For neuropathic pain, treatment focuses on nerve specific therapies such as: - Antidepressants - Anticonvulsants - Topical painkillers - Lifestyle modification - Natural remedies THE ROLE OF VITAMINS B1, B6 AND B12. The B-vitamins especially B1, B6 and B12 play a huge role in neuropathic pain. This is because they’re essential for nerve function, nerve regeneration and reduction of inflammation. What’s more? It is scientifically proven. Let’s get into the benefits.