VITAMIN B1 (Thiamine) - The nerve protector Thiamine is essential for nerve function and energy metabolism. How does it relieve pain? - It protects the nerves from oxidative damage and inflammation - It supports production of acetylcholine, a neurotransmitter that helps with nerve signaling - It prevents diabetic neuropathy. A study published in the journal of clinical medicine found that thiamine supplementation significantly reduced neuropathic pain in diabetic patients.