🌟 *New Insights on ARDS: The Future of Diagnosis and Treatment* 🌟 Acute Respiratory Distress Syndrome (ARDS) remains a major challenge in critical care, with high mortality rates and complex pathophysiology. This review highlights the evolution of ARDS definitions, from the 1967 description to the latest 2024 global definition, which now includes noninvasive respiratory support and lung ultrasound. 🔬 *Key Takeaways:* 1️⃣ *Heterogeneity Matters:* ARDS isn’t one-size-fits-all. Different subphenotypes (hyper-inflammatory vs. hypo-inflammatory) respond differently to treatments. 2️⃣ *Personalized Medicine:* Advances in omics (genomics, proteomics, metabolomics) are paving the way for tailored therapies. 3️⃣ *Ventilation Strategies:* Low tidal volume and prone positioning are crucial, but PEEP levels must be adjusted based on individual lung mechanics. 4️⃣ *COVID-19 Impact:* The pandemic revealed unique ARDS presentations, emphasizing the need for adaptable treatment approaches. 1/2