سؤال من احد الزملاء استخدام انتنال فى حالات النزلات المعويه المعلومات دى فعلا حلوه ومكثفه احفظها عندك واقرأها براحتك بعد كده Plz proper use of medication in children 👦 Ezz Clinical Cards ✅ Topic: Use of Antinal (Nifuroxazide) in Acute Gastroenteritis in Children ✅ Key Message: Nifuroxazide is not routinely recommended in the treatment of acute gastroenteritis in children. ✅ What You Should Know: • Acute gastroenteritis is usually viral in origin in children — treatment is mainly supportive with rehydration. • Nifuroxazide, a nitrofuran derivative, is a locally acting intestinal antiseptic with limited systemic absorption. • Evidence is insufficient to recommend its routine use in children, especially in high-income and guideline-driven settings. ✅ When Might It Be Used? • In some countries, it is used empirically for presumed bacterial diarrhea when: • There is no access to rapid stool testing. • Symptoms suggest possible bacterial etiology (e.g., fever, dysentery, travel-related diarrhea). • A short course (≤3 days) may be used cautiously in older children. ✅ Clinical Pearls: • Oral rehydration therapy (ORT) remains the cornerstone of treatment. • Overuse of antimicrobials like Nifuroxazide may promote antimicrobial resistance. • Do not use Nifuroxazide in: • Infants <2 months. • Suspected bloody diarrhea, systemic infection, or in place of proper antibiotics. ✅ Guidelines Reference: • ESPGHAN/ESPID 2014 Guidelines: Antimicrobials generally not recommended in routine acute diarrhea. • WHO 2023 Guidelines: Emphasize ORT, zinc, and nutritional support over antimicrobials. ✅ Bonus Tip: If in doubt, hydrate first — medicate only when justified. Prof Mohammed Ezz El Regal