EUP 🇪🇬
May 24, 2025 at 08:33 AM
صباح الفل
الدومبريدون (الموتليوم)
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خلى بالك من الثلاث حاجات دول
🚨خلى بالك فى الاطفال اللى اقل من سنه
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🚨خلى بالك مش تستخدمه مع المضادات الحيويه macrolids as Azithromycin, clarithromycin, and erythromycin
المزيد
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Ezz Clinical Cards – Pediatric GI Drug Pearls
Drug #25: Motilium (Domperidone)
Peripheral dopamine-2 receptor antagonist
✅ Indications:
• Gastric dysmotility
• Persistent vomiting (e.g., post-viral, cyclic vomiting syndrome)
• Reflux-related symptoms in older infants and children
• Delayed gastric emptying in neurologically impaired children
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✅ Clinical Pearls:
1️⃣ Prokinetic agent – increases gastric emptying and enhances lower esophageal sphincter tone.
2️⃣. Pediatric dosing (oral suspension):
• 0.25–0.5 mg/kg/dose, 3 times/day
• Administer 30 minutes before meals
3️⃣ Suppository form – useful when oral route is compromised (e.g., vomiting).
4️⃣ Caution in infants <1 year – higher risk of extrapyramidal side effects and cardiac arrhythmias.
5️⃣ QT prolongation risk:
• Avoid in children with cardiac disease or when combined with macrolides, azoles, or other QT-prolonging drugs.
6️⃣ Use under specialist supervision for chronic cases – do not use for >7–10 days without reassessment.
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✅ Bonus Tip:
Motilium may help with vomiting or motility-related symptoms—but always combine with feeding review, positional strategies, and underlying cause management.
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