
CSIR-CDRI Lucknow
June 2, 2025 at 06:11 AM
🚨 Just Published in Biochemical Pharmacology
A new study from Dr. Durga Prasad Mishra’s lab at CSIR-Central Drug Research Institute, Lucknow, India, led by Abhishek Nirwan, Ph.D., explores the therapeutic potential of Coagulin-L, a natural compound derived from Withania coagulans, in treating liver fibrosis.
The study demonstrates that Coagulin-L modulates the PI3K/AKT signaling pathway, suppresses hepatic stellate cell activation, reduces VEGF expression and collagen deposition—ultimately improving liver function in a preclinical model of MASH.
🔗 Read the full paper: https://www.sciencedirect.com/science/article/pii/S0006295225002412?via%3Dihub
Congratulations to all authors!
Abhishek Nirwan, Ph.D., Deepika Saini, Jaspreet kaur, Abinash Swain, Abhisek Sarkar, Prem Prakash Yadav and Durga Prasad Mishra
#liverfibrosis

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