CSIR-CDRI Lucknow

CSIR-CDRI Lucknow

5/28/2025, 6:04:01 AM

🚨 #JustPublished in Journal of Medicinal Chemistry A new study from CSIR-Central Drug Research Institute, Lucknow, India, led by Dr. Akhilesh K. Tamrakar and Dr. K.V. Sashidhara, reports the discovery of phthalazinone-triazole hybrids synthesized via Click chemistry. The paper, with Ajay Kishor Kushawaha and Arvind Kumar Jaiswal as lead authors, highlights these compounds' ability to stimulate GLUT4 translocation in skeletal muscle, an important mechanism for glucose regulation. This work opens new avenues for the development of effective therapies to manage diabetes. 👏 Congratulations to all authors!! Ajay Kishor Kushawaha, Arvind kumar Jaiswal, Pawan Kumar, Dr. Sarita Katiyar, Rahul Baghel, Hemlata Bhatt, Jay Gupta, Alisha Ansari, Poonam Yadav, Ishbal Ahmad, Abhijit Deb Choudhury, Rabi Sankar Bhatta, Akhilesh K. Tamrakar and Koneni V. Sashidhara 🔗 Read the full article: https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.4c02615 #DiabetesResearch #MedicinalChemistry

CSIR-CDRI Lucknow

5/28/2025, 5:50:29 AM

🚨#JustPublished in Journal of Applied Nanomaterials. New research from Dr. Manish K. Chourasia’s group at CSIR-Central Drug Research Institute, Lucknow, India, with Rafquat Rana as lead author, presents a biomimetic nanoformulation (NM@MCN-MM) designed to tackle key challenges in neurodegenerative diseases like Alzheimer’s and Parkinson’s. By combining neural cell membranes with ceria nanoparticles, the team developed a nano-system that can cross the blood-brain barrier, target damaged brain regions, and address mitochondrial dysfunction, oxidative stress, and calcium imbalance—hallmarks of neurodegeneration. This innovative approach shows great potential for future therapies aimed at improving brain health. 🧠💡 Congratulations to all authors! Rafquat Rana, Shourya Tripathi, Keerti Mishra, Pavan K. Yadav, Ph.D., Prem Narayan Yadav and Manish K. Chourasia 🔗 Read the full article: https://pubs.acs.org/doi/10.1021/acsanm.5c00545 #Neurodegeneration #Nanomedicine

CSIR-CDRI Lucknow

5/30/2025, 4:59:56 AM

CSIR-IICB recruits scientists , apply on or before 27 June 2025. Find more details here : https://iicb.res.in/news/recruitment-of-scientist-senior-scientist-principal-scientist-randc-610-2025#

CSIR-CDRI Lucknow

5/16/2025, 11:21:01 AM

🔷 *Welcome Dr. Suresh Kumar Battina to CSIR-CDRI!* 🔷 We are pleased to welcome Dr. Suresh Kumar Battina to CSIR-Central Drug Research Institute, Lucknow, India as a Scientist in the Business Development and Intellectual Property Unit. Dr. Suresh completed his *Ph.D. in Organic Chemistry from CSIR-IICT, Hyderabad,* under the mentorship of Dr. P. Radha Krishna, specializing in the total synthesis of natural products and novel synthetic methodologies. With over seven years of experience in IP management in the pharmaceutical industry and having qualified the Patent Agent Examination in 2025, he brings a unique blend of academic depth and industry insight. We look forward to his strategic contributions in advancing innovation, technology transfer, and IP-led growth at CSIR-CDRI. 🌟 Welcome aboard, Dr. Suresh! 🌟

CSIR-CDRI Lucknow

6/3/2025, 10:08:25 AM

Congratulations to Mr. Abhinav Singh on successfully completing his Ph.D. viva-voce under the supervision of Dr. Kumaravelu Jagavelu at CSIR-Central Drug Research Institute, Lucknow, India! Wishing him all the best for the future. #PhDSuccess

CSIR-CDRI Lucknow

6/2/2025, 6:11:50 AM

🚨 Just Published in Biochemical Pharmacology A new study from Dr. Durga Prasad Mishra’s lab at CSIR-Central Drug Research Institute, Lucknow, India, led by Abhishek Nirwan, Ph.D., explores the therapeutic potential of Coagulin-L, a natural compound derived from Withania coagulans, in treating liver fibrosis. The study demonstrates that Coagulin-L modulates the PI3K/AKT signaling pathway, suppresses hepatic stellate cell activation, reduces VEGF expression and collagen deposition—ultimately improving liver function in a preclinical model of MASH. 🔗 Read the full paper: https://www.sciencedirect.com/science/article/pii/S0006295225002412?via%3Dihub Congratulations to all authors! Abhishek Nirwan, Ph.D., Deepika Saini, Jaspreet kaur, Abinash Swain, Abhisek Sarkar, Prem Prakash Yadav and Durga Prasad Mishra #LiverFibrosis

CSIR-CDRI Lucknow

5/28/2025, 5:16:16 AM

🎓 Congratulations to Ms. SAPNA SRIVASTAVA, PhD student of Dr.Dibyendu Banerjee from CSIR-Central Drug Research Institute, Lucknow, India, for enrolling at RMIT University in the prestigious Joint PhD Program between AcSIR (India) and RMIT University (Australia)! 🌏📚 Her doctoral research, “Study of Resistance Mechanisms for Immune Checkpoint Blockade Therapy in Cancer Cells,” aims to unravel how cancer cells evade immunotherapy and to identify novel immune checkpoint molecules that can be targeted to overcome therapy resistance. Currently working with the CAVA: Cancer, Ageing and Vaccine Laboratory (RMIT), of Prof. Magdalena Plebanski, Sapna is making strides toward developing more effective cancer immunotherapies. 🧬💡 We wish her continued success in this impactful journey!