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May 26, 2025 at 03:19 PM
Are Stool H. pylori Antigen Tests Being Abused in Pediatric Diagnosis?
Clinical Dilemma:
A 6-year-old with chronic abdominal pain and no alarm features is tested with a stool H. pylori antigen — it’s positive. Treatment is started immediately. Was this justified?
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What’s the Controversy?
• Stool H. pylori antigen tests are widely used due to ease and non-invasiveness.
• However, in children, testing should be limited to those with clear symptoms and indications.
• Guidelines (ESPGHAN/NASPGHAN) recommend diagnosing H. pylori by endoscopy and biopsy, not stool test alone.
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Current Best Practice:
• Do not use stool antigen testing to screen or diagnose H. pylori without GI indications.
• Reserve testing for treatment follow-up — not initial diagnosis.
• Use endoscopy-based diagnosis in children with ulcer-like symptoms or alarm signs.
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Bonus Insight:
A positive stool test without symptoms is not an indication to treat. H. pylori can be a harmless colonizer in many children.
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