🔬Forum of Clinical Laboratories💉
June 14, 2025 at 05:41 PM
📲🩸 *Russell bodies*
Are eosinophilic, spherical inclusions found within the cytoplasm of plasma cells.
They are formed due to the abnormal accumulation of immunoglobulins, either excess or misfolded, within the endoplasmic reticulum of these cells.
These plasma cells containing Russell bodies are sometimes referred to as Mott cells.
*Here's a more detailed explanation:*
_a *Formation:*_
- Russell bodies arise from the disturbed secretion of immunoglobulins in plasma cells.
- When these immunoglobulins accumulate within the endoplasmic reticulum, they form these characteristic inclusions.