ICTP-SAIFR announces the opening of two Simons-FAPESP tenure-track research professor positions to begin in 2026, with the first in connections of physics to biology and the second in all other areas related to theoretical physics. Salary includes generous fellowships from the Simons Foundation and the São Paulo Research Funding Agency (FAPESP), and additional grants are available for research/travel from state and national funding agencies. Researchers can also use ICTP-SAIFR funds for graduate students, postdocs and visitors, as well as participate in ICTP-SAIFR visitor agreements. Although applications will be accepted until the positions are filled, candidates are strongly encouraged to apply before *August 31, 2025*. *More information:* https://www.ictp-saifr.org/simonsfapesp2025/