نبض المختبر Lab Pulse
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قناة نبض المختبر 🔬❤️ *طبتم وطاب محياكم* 📜 رسالتنا: تبسيط المعرفة المخبرية الطبية ونشر الوعي الصحي في المجتمع من خلال محتوى علمي موثوق وسهل الفهم. 🧪 نقدم لكم: - معلومات مبسطة عن الفحوصات المخبرية وأهميتها - شرح نتائج التحاليل الطبية الشائعة - نصائح صحية مستندة على البراهين العلمية - إضاءات على أحدث المستجدات في عالم المختبرات الطبية 🎯 هدفنا: بناء جسر معرفي يربط بين المختبر الطبي والمجتمع، لنساهم معاً في رفع مستوى الوعي الصحي وتحسين جودة الحياة. 👥 انضموا إلينا في هذه الرحلة العلمية المثمرة، وكونوا جزءاً من نشر المعرفة الصحية في مجتمعنا. 🌟 سعيد محمد الجعفري Lab Pulse Channel 🔬❤️ 📜 Our Mission: Simplifying medical laboratory knowledge and spreading health awareness in the community through reliable and easy-to-understand scientific content. 🧪 We Provide: - Simplified information about laboratory tests and their importance - Explanation of common medical test results - Evidence-based health tips - Highlights on the latest developments in the medical laboratory field 🎯 Our Goal: Building a knowledge bridge between the medical laboratory and the community, to contribute together in raising health awareness and improving quality of life. 👥 Join us on this fruitful scientific journey, and be part of spreading health knowledge in our community. 🌟 Said Al Jaafari
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3. ALT greater than AST → Viral or Autoimmune Hepatitis When ALT is higher than AST, particularly in significant elevations, it is often due to: • Acute viral hepatitis (A, B, C) • Autoimmune hepatitis ALT is more liver-specific than AST and tends to dominate in viral processes.
2. ALP greater than AST and ALT → Cholestatic Pattern This pattern points to problems in bile flow or bile ducts. Common causes include: • Biliary obstruction (gallstones, strictures) • Primary Biliary Cholangitis (PBC) • Primary Sclerosing Cholangitis (PSC) Cholestasis leads to elevated ALP, and often bilirubin if the obstruction is significant.
6. Isolated ALP Elevation → Bone Disease If only ALP is elevated (with normal GGT), think of bone-related conditions such as: • Paget’s disease • Bone metastases • Osteomalacia or rickets • Physiologic growth in children
4. AST greater than ALT (with ratio >2:1) → Alcoholic Liver Disease This is a classic finding in alcohol-related liver damage. It occurs due to: • Mitochondrial damage from alcohol preferentially increases AST. • Vitamin B6 deficiency, more common in alcoholics, suppresses ALT production. It is seen in chronic alcohol use, alcoholic hepatitis, or cirrhosis due to alcohol.
5. Elevated ALP along with GGT → Hepatic Source When both alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) are elevated, the source of ALP is likely hepatic rather than bone. This helps differentiate liver vs. bone disease causes. Note: GGT is not elevated in bone disorders, so its rise confirms a hepatic origin of ALP elevation.
7. Isolated GGT Elevation → Alcohol Use or Enzyme Induction A rise in GGT alone may indicate: • Chronic alcohol consumption • Enzyme induction by drugs such as phenytoin or phenobarbital • Non-specific hepatic stress GGT is sensitive but not specific; its use is best as a confirmatory marker alongside ALP.
Liver Enzyme Pattern Interpretation 1. AST and ALT greater than ALP → Hepatocellular Pattern This indicates damage to liver cells (hepatocytes). Common causes include: • Viral hepatitis (e.g., Hepatitis B, C) • Autoimmune hepatitis • Drug-induced liver injury (e.g., paracetamol overdose, anti-TB drugs) These conditions typically cause a significant rise in transaminases (ALT and AST), with ALT usually more elevated than AST in non-alcoholic causes.